Semi-synthesis of a protease-activatable collagen targeting probe.
نویسندگان
چکیده
A protease-activatable collagen targeting probe (proCNA35) is synthesized by conjugation of a synthetic collagen fragment to the collagen binding protein CNA35 via a protease-cleavable linker. Cleavage of the linker by MMP1 releases the intramolecular inhibition of the collagen binding site and restores its collagen binding capacity.
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عنوان ژورنال:
- Chemical communications
دوره 47 28 شماره
صفحات -
تاریخ انتشار 2011